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Tumor progression and metastasis proceedings of a Triton Biosciences-Smith, Kline & French-UCLA symposium held in Keystone, Colorado, April 6-12, 1987 by

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Published by A.R. Liss in New York .
Written in English


  • Metastasis -- Congresses.,
  • Tumors -- Growth -- Congresses.,
  • Cancer -- Genetic aspects -- Congresses.,
  • Neoplasm Invasiveness -- congresses.,
  • Neoplasm Metastasis -- congresses.

Book details:

Edition Notes

Statementeditors, Garth L. Nicolson, Isaiah J. Fidler.
SeriesUCLA symposia on molecular and cellular biology ;, new ser., v. 78
ContributionsNicolson, Garth L., Fidler, Isaiah J., 1936-, Triton Biosciences, Inc., Smith, Kline & French Laboratories., University of California, Los Angeles.
LC ClassificationsRC269.5 .T85 1988
The Physical Object
Paginationxx, 302 p. :
Number of Pages302
ID Numbers
Open LibraryOL2033212M
ISBN 100845126776
LC Control Number88009120

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Mathematical Modeling in Tumor Growth and Progression (Invasion and Metastasis, ): Medicine & Health Science Books @ The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph presents a .   Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume in the International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin Book Edition: 1.   By applying those technologies for detection of genetic and epigenetic determinants for tumor progression and metastasis, it will be possible to diagnose the clinical aggressiveness of cancer at bedside in future. According to the concept of tumor cell heterogeneity, highly metastatic cells are present as a sub-population in a primary by:

In metastatic progression, time and the failure factors indicated in the gure above, play a crucial role in the prognosis and treatment of the patient with cancer, as shown in the model of the. BMA Medical Book Awards Highly Commended in Oncology Category! The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. . Turning on the angiogenic switch is a crucial point in the progression of tumors toward metastasis as angiogenic tumors greatly increase the pace of tumor growth. In addition to increasing the rate of tumor growth, angiogenesis increases vascular density around the tumor providing a door for metastatic cells to enter the general circulation where they can find a new tissue for seeding secondary tumors.   Metastatic disease is responsible for approximately 90% of cancer deaths. For successful dissemination and metastasis, cancer cells must evade detection and destruction by the Author: Hannah Garner, Karin E. de Visser, Karin E. de Visser.

  Integrin-mediated sensing, stiffening and remodelling of the tumour stroma are key steps in cancer progression supporting invasion, acquisition of cancer stem cell characteristics and drug Cited by: The Tumor Progression and Metastasis [TPM] Study Section reviews grant applications on basic mechanisms of cancer progression, metastasis, and angiogenesis. Special emphasis is placed on .   Besides the role of RANKL in tumor-induced osteolysis, bone destruction, and skeletal tumor progression, the authors also provided arguments for a direct pro-metastatic effect of RANKL, as RANKL also stimulates metastasis via activity on RANK-expressing cancer . Moreover, the FGFR4 Arg allele was associated with early lymph node metastasis and advanced tumor-node-metastasis (TNM) stage in 82 colon cancer patients. Consistent with this finding, MDA-MB mammary tumor .